![]() ![]() ![]() ![]() In South Korea, where avian influenza virus subtypes H 3N2, H5N1, H6N1, and H9N2 circulate or have been detected, 3 genetically similar canine influenza virus ( H 3N2) strains of avian origin (A/canine/Korea/01/2007, A/canine/Korea/02/2007, and A/canine/Korea/03/2007) were isolated from dogs exhibiting severe respiratory disease. Song, Daesub Kang, Bokyu Lee, Chulseung Jung, Kwonil Ha, Gunwoo Kang, Dongseok Park, Seongjun Park, Bongkyun Oh, Jinsik Transmission of Avian Influenza Virus ( H 3N2) to Dogs We discuss our results in relation to the mechanism of transfer of influenza viruses between species We find that Î☒,6-linked analogs are bound by both human and avian HAs in a cis conformation, and that the incompatibility of an Î☒,6-linked receptor with the Î☒, 3-linkage-specific H 3 avian HA-binding site is partially resolved by a small change in the position and orientation of the sialic acid. Comparing the structures of complexes in which an Î☒, 3-linked receptor analog is bound to the H 3 avian HA or to an H5 avian HA leads to the suggestion that all avian influenza HAs bind to their preferred Î☒, 3-linked receptors similarly, with the analog in a trans conformation about the glycosidic linkage. We have also analyzed complexes formed by the HA with sialopentasaccharides in which the terminal sialic acid is in either Î☒, 3- or Î☒,6-linkage to galactose. We find that structurally significant differences between the avian and the human HAs are restricted to the receptor-binding site particularly the substitutions Q226L and G228S that cause the site to open and residues within it to rearrange, including the conserved residues Y98, W153, and H183. ![]() We have determined the structure of the HA of an avian influenza virus, A/duck/Ukraine/63, a member of the same antigenic subtype, H 3, as the virus that caused the 1968 Hong Kong influenza pandemic, and a possible progenitor of the pandemic virus. International Nuclear Information System (INIS) X-ray structure of the hemagglutinin of a potential H 3 avian progenitor of the 1968 Hong Kong pandemic influenza virus ![]()
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